UK MPs say yes to three-person babies

MPs have voted in favour of the creation of babies with DNA from two women and one man, in an historic move.

The UK is now set to become the first country to introduce laws to allow the creation of babies from three people.

In a free vote in the Commons, 382 MPs were in favour and 128 against the technique that stops genetic diseases being passed from mother to child. During the debate, ministers said the technique was "light at the end of a dark tunnel" for families. A further vote is required in the House of Lords. It everything goes ahead then the first such baby could be born next year. Proponents said the backing was "good news for progressive medicine" but critics say they will continue to fight against the technique that they say raises too many ethical and safety concerns.

Estimates suggest 150 three-person babies could be born each year.

Prime Minister David Cameron said: "We're not playing god here, we're just making sure that two parents who want a healthy baby can have one."

Life-saving

The method, which was developed in Newcastle, should help women like Sharon Bernardi, from Sunderland, who lost all seven of her childrento mitochondrial disease.

Ms Bernadi said was "overwhelmed" by the decision.

Mitochondria are the tiny compartments inside nearly every cell of the body that convert food into useable energy. They have their own DNA, which does not affect characteristics such as appearance.

Defective mitochondria are passed down only from the mother. They can lead to brain damage, muscle wasting, heart failure and blindness.

The technique uses a modified version of IVF to combine the DNA of the two parents with the healthy mitochondria of a donor woman.

It results in babies with 0.1% of their DNA from the second woman and is a permanent change that would be passed down through the generations.

Debate

In the Commons debate, Public Health Minister Jane Ellison told the House: "This is a bold step for parliament to take, but it is a considered and informed step.

"This is world leading science within a highly respected regulatory regime.

"And for the many families affected, this is light at the end of a very dark tunnel."

Fiona Bruce, the MP for Congleton, countered: "[This] will be passed down generations, the implications of this simply cannot be predicted.

"But one thing is for sure, once this alteration has taken place, as someone has said, once the gene is out of the bottle, once these procedures that we're asked to authorise today go ahead, there will be no going back for society."

The debate in Commons also repeatedly struggled with whether the move would constitute "genetic modification".

Robert Flello, who represents Stoke-on-Trent South, said he feared "families will be let down tragically" due to the uncertainties in the technique and that society would be "up in arms" if this was a proposal for genetically modified crops.

But Frank Dobson, a former former health secretary, argued uncertainty was "the nature of medicine and science" and that IVF would not have gone ahead if absolute certainty was needed.